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Chemical structure of CAS 115256-11-6

Dofetilide

In Stock•Starting at $11 for 10 mg•Purity ≥ 98%
CAS No.115256-11-6
MDL No.MFCD00869707
MFC19H27N3O5S2
MW441.60
InChI KeyIXTMWRCNAAVVAI-UHFFFAOYSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
10 mg98%$11In Stock
50 mg98%$25In Stock
100 mg98%$30In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

Dofetilide is a tertiary amino compound with an N-ethyl-N-methylethanamine backbone substituted by a 4-[(methylsulfonyl)amino]phenoxy group and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms. It functions as an anti-arrhythmia drug and potassium channel blocker, and is classified as a sulfonamide, aromatic ether, and tertiary amino compound.

CAS No.115256-11-6
Product NameDofetilide

Biological Targets

KCNH2

Associated Conditions

familial long QT syndrome·atrial flutter·cardiac arrhythmia·heart failure·Ventricular arrhythmia·
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Intravenous antiarrhythmic agents.

Current opinion in cardiology • Vol. 16, Issue 1 • 2001
PMID: 11124714DOI: 10.1097/00001573-200101000-00003

Effects of EGIS-7229 (S 21407), a novel class III antiarrhythmic drug, on myocardial refractoriness to electrical stimulation in vivo and in vitro.

Journal of cardiovascular pharmacology • Vol. 37, Issue 1 • 2001
PMID: 11152377DOI: 10.1097/00005344-200101000-00009

Effect of dofetilide on the pharmacokinetics of digoxin.

The American journal of cardiology • Vol. 87, Issue 2 • 2001
PMID: 11152855DOI: 10.1016/s0002-9149(00)01332-1

[3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel?

European journal of pharmacology • Vol. 412, Issue 3 • 2001
PMID: 11166283DOI: 10.1016/s0014-2999(01)00731-2

Documentation