Trabectedin is a tetrahydroisoquinoline alkaloid derived from the Caribbean tunicate Ecteinascidia turbinata. It is used to treat soft tissue sarcoma and relapsed ovarian cancer. Trabectedin functions as an antineoplastic agent, marine metabolite, anti-inflammatory agent, angiogenesis modulator, and alkylating agent. Structurally, it is an organic heteropolycyclic compound, featuring azaspiro, oxaspiro, and bridged frameworks, and contains lactone, polyphenol, acetate ester, hemiaminal, sulfide, tertiary amine, and isoquinoline functionalities.
