Concentration-QT modelling of the novel DHFR inhibitor P218 in healthy male volunteers.
British journal of clinical pharmacology • Vol. 88, Issue 1 • 2022
Transgenic pyrimethamine-resistant plasmodium falciparum reveals transmission-blocking potency of P218, a novel antifolate candidate drug.
International journal for parasitology • Vol. 51, Issue 8 • 2021
Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study.
The American journal of tropical medicine and hygiene • Vol. 104, Issue 4 • 2021
First-in-human clinical trial to assess the safety, tolerability and pharmacokinetics of P218, a novel candidate for malaria chemoprotection.
British journal of clinical pharmacology • Vol. 86, Issue 6 • 2020