Alisertib is an organic heterotricyclic compound with a 5H-pyrimido[5,4-d][2]benzazepine core substituted at positions 2, 7, and 9 by chloro, (4-carboxy-3-methoxyphenyl)amino, and 2-fluoro-6-methoxyphenyl groups, respectively. It is an aurora A kinase inhibitor (IC50 ~1 nM) and functions as an antineoplastic agent, apoptosis inducer, and autophagy inducer. It is classified as an organochlorine compound, a monomethoxybenzene, a member of monofluorobenzenes, a methoxybenzoic acid, and a secondary amino compound.
