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Chemical structure of CAS 1023650-66-9

Pf-03882845

In Stock•Starting at $224 for 1 mg•Purity ≥ 99.63%
CAS No.1023650-66-9
MDL No.N/A
MFC24H22ClN3O2
MW419.90
InChI KeyXNULRSOGWPFPBL-REWPJTCUSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mg99.63% ;$224In Stock
5 mg99.63% ;$519In Stock
10 mg99.63% ;$767In Stock
25 mg99.63% ;$1295In Stock
50 mg99.63% ;$1824In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.1023650-66-9
Product NamePf-03882845

Biological Targets

NR3C2

Associated Conditions

diabetic nephropathy·type 2 diabetes mellitus
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist.

Journal of medicinal chemistry • Vol. 57, Issue 10 • 2014
PMID: 24738581DOI: 10.1021/jm500206r

PF-03882845, a non-steroidal mineralocorticoid receptor antagonist, prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy.

Frontiers in pharmacology • Vol. 4 • 2013
PMID: 24133446PMC: PMC3796291DOI: 10.3389/fphar.2013.00115

Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.

Journal of medicinal chemistry • Vol. 53, Issue 16 • 2010
PMID: 20672822DOI: 10.1021/jm100505n

Documentation