BMS-754807 is a pyrrolotriazine, specifically a pyrrolo[2,1-f][1,2,4]triazine, substituted at position 2 with the pyrrolidine nitrogen of (2S)-N-(6-fluoropyridin-3-yl)-2-methylprolinamide and at position 4 with a (5-cyclopropyl-1H-pyrazol-3-yl)amino group. It is a potent, reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases, acting as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an antineoplastic agent. It belongs to the classes of pyrrolotriazines, pyrazoles, pyridines, and pyrrolidines.
