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Chemical structure of CAS 1000669-72-6

Kw-2449

CAS No.1000669-72-6
MDL No.MFCD18385006
MFC20H20N4O
MW332.40
InChI KeyYYLKKYCXAOBSRM-JXMROGBWSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT→

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Product Information

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone is an indazole derivative.

CAS No.1000669-72-6
Product NameKw-2449

Biological Targets

AURKA·AURKB·ABL1·FLT3

Associated Conditions

acute myeloid leukemia
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Comprehensive analysis of kinase inhibitor selectivity.

Nature biotechnology • Vol. 29, Issue 11 • 2011
PMID: 22037378DOI: 10.1038/nbt.1990

Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Chemistry & biology • Vol. 17, Issue 11 • 2010
PMID: 21095574DOI: 10.1016/j.chembiol.2010.09.010

KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation.

Blood • Vol. 114, Issue 8 • 2009
PMID: 19541823DOI: 10.1182/blood-2009-01-199307

Documentation

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