Afoxolaner
CandidateCAS: 1093861-60-9
Sample Stock:
Afoxolaner is a potent isoxazoline ectoparasiticide indicated for the treatment and prevention of flea and tick infestations (Ixodes, Rhipicephalus, Dermacentor) in canines. Its mechanism of action involves the selective antagonism of GABA- and glutamate-gated chloride channels in the invertebrate nervous system, inducing hyperexcitation and fatal paralysis. Characterized by rapid systemic absorption and an extended elimination half-life, Afoxolaner supports a once-monthly oral dosing regimen and is frequently formulated with milbemycin oxime to provide broad-spectrum protection against both ectoparasites and endoparasites.
Related Information
Purity:98%+
Registration:GMP/DMF
Key Intermediates
3 Items| Structure | Name | CAS No. | Sample Stock | MDL No. | Details |
|---|---|---|---|---|---|
 | 4-Acetylnaphthalene-1-carboxylic acid | 131986-05-5 | MFCD24480081 | ||
![1-[3-Chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanone structure](https://static.dempochem.com/structures-bw/6936efc456dfcbb81ec1fd42.svg) | 1-[3-Chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanone | 1125812-58-9 | MFCD19440960 | ||
![4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]naphthalene-1-carboxylic acid structure](https://static.dempochem.com/structures-bw/6936f03b56dfcbb81ec1fd43.svg) | 4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]naphthalene-1-carboxylic acid | 1308362-48-2 | - |