HomeProductsBioactive CompoundsProtein Kinase Targetsc-Met/HGFRPf-04217903
Chemical structure of CAS 956905-27-4

Pf-04217903

In Stock•Starting at $31 for 1 mg•Purity ≥ 99%
CAS No.956905-27-4
MDL No.MFCD12407410
MFC19H16N8O
MW372.40
InChI KeyPDMUGYOXRHVNMO-UHFFFAOYSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mg99%$31In Stock
5 mg99%$36In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

2-[4-[3-(6-quinolinylmethyl)-5-triazolo[4,5-b]pyrazinyl]-1-pyrazolyl]ethanol is a quinoline derivative.

CAS No.956905-27-4
Product NamePf-04217903

Biological Targets

MET

Associated Conditions

neoplasm
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer.

Journal of medicinal chemistry • Vol. 55, Issue 18 • 2012
PMID: 22924734DOI: 10.1021/jm300967g

Prediction of oral pharmacokinetics of cMet kinase inhibitors in humans: physiologically based pharmacokinetic model versus traditional one-compartment model.

Drug metabolism and disposition: the biological fate of chemicals • Vol. 39, Issue 3 • 2011
PMID: 21098644DOI: 10.1124/dmd.110.035857

In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase.

Drug metabolism and disposition: the biological fate of chemicals • Vol. 38, Issue 8 • 2010
PMID: 20444863DOI: 10.1124/dmd.110.033555

Documentation