HomeProductsBioactive CompoundsPI3K/Akt/mTOR PathwaymTORKu-0063794
Chemical structure of CAS 938440-64-3

Ku-0063794

CAS No.938440-64-3
MDL No.MFCD22666594
MFC25H31N5O4
MW465.50
InChI KeyRFSMUFRPPYDYRD-CALCHBBNSA-N

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Product Information

Ku-0063794 is a pyridopyrimidine mTOR inhibitor with anti-tumour activity. It functions as an mTOR inhibitor and antineoplastic agent. It belongs to morpholines, pyridopyrimidines, monomethoxybenzene, tertiary amino compounds, and benzyl alcohols.

CAS No.938440-64-3
Product NameKu-0063794
Heavy Atom Count34Rotatable Bond Count5
Atom Stereo Count2Bond Stereo Count0
HBA9HBD1
TPSA93.070 ŲCharge0
Exact Mass465.23760Complexity1157.50
pKa11.433XLogP2.643

Related Articles

Studies related to this compound and its mechanism of action

The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition.

British journal of cancer • Vol. 106, Issue 8 • 2012
PMID: 22415236PMC: PMC3326670DOI: 10.1038/bjc.2012.70

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levels.

Oncotarget • Vol. 3, Issue 8 • 2012
PMID: 22885370PMC: PMC3478458DOI: 10.18632/oncotarget.579

Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.

Journal of medicinal chemistry • Vol. 54, Issue 5 • 2011
PMID: 21322566PMC: PMC3090687DOI: 10.1021/jm101520v

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).

The Biochemical journal • Vol. 421, Issue 1 • 2009
PMID: 19402821PMC: PMC2708931DOI: 10.1042/BJ20090489

Documentation

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