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Chemical structure of CAS 881375-00-4

KU-0060648

CAS No.881375-00-4
MDL No.MFCD17214218
MFC33H34N4O4S
MW582.70
InChI KeyAATCBLYHOUOCTO-UHFFFAOYSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
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Custom synthesis and bulk supply options are available upon request.

Product Information

2-(4-ethylpiperazin-1-yl)-N-[4-[2-(4-morpholinyl)-4-oxo-1-benzopyran-8-yl]-1-dibenzothiophenyl]acetamide is a dibenzothiophene derivative.

CAS No.881375-00-4
Product NameKU-0060648
Acute ToxicAcute Toxic
Signal Word:Danger
HCode:H301
PCode:P264-P270-P301+P316-P321-P330-P405-P501

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Studies related to this compound and its mechanism of action

1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.

Journal of medicinal chemistry • Vol. 56, Issue 16 • 2013
PMID: 23855836DOI: 10.1021/jm400915j

Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K.

Molecular cancer therapeutics • Vol. 11, Issue 8 • 2012
PMID: 22576130PMC: PMC3428850DOI: 10.1158/1535-7163.MCT-11-0535

The DNA-dependent protein kinase.

Genes & development • Vol. 13, Issue 8 • 1999
PMID: 10215620DOI: 10.1101/gad.13.8.916

Differential implications of the oncogene-tumor suppressor gene complex in the geneses of 19 human neoplasias. Evidence in support of the steroid carcinogenesis hypothesis.

Anticancer research • Vol. 17, Issue 3C • 1997
PMID: 9216703

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