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Chemical structure of CAS 82964-04-3

Tolrestat

In Stock•Starting at $189 for 10 mg•Purity ≥ 98%
CAS No.82964-04-3
MDL No.N/A
MFC16H14F3NO3S
MW357.30
InChI KeyLUBHDINQXIHVLS-UHFFFAOYSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
10 mg98%$189In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

Tolrestat is a naphthalene derivative and functions as an aldehyde reductase (EC 1.1.1.21) inhibitor.

CAS No.82964-04-3
Product NameTolrestat

Biological Targets

AKR1B1

Associated Conditions

diabetes mellitus
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Pathogenesis of diabetic neuropathy--do hyperglycemia and aldose reductase inhibitors affect neuroactive steroid formation in the rat sciatic nerves?

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association • Vol. 110, Issue 1 • 2002
PMID: 11835121DOI: 10.1055/s-2002-19990

Synthesis and aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones.

Bioorganic & medicinal chemistry • Vol. 10, Issue 4 • 2002
PMID: 11836118DOI: 10.1016/s0968-0896(01)00366-2

Effects of aminoguanidine and tolrestat on the development of ocular and renal structural changes in experimental diabetic rats.

Diabetes, obesity & metabolism • Vol. 4, Issue 1 • 2002
PMID: 11874446DOI: 10.1046/j.1463-1326.2002.00182.x

Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning.

Circulation research • Vol. 91, Issue 3 • 2002
PMID: 12169650DOI: 10.1161/01.res.0000029970.97247.57

Documentation