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Chemical structure of CAS 80012-43-7

Epinastine

CAS No.80012-43-7
MDL No.MFCD00865648
MFC16H15N3
MW249.31
InChI KeyWHWZLSFABNNENI-UHFFFAOYSA-N

Pricing & Availability

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Custom synthesis and bulk supply options are available upon request.

Product Information

Epinastine is a benzazepine, specifically 6,11-dihydro-5H-dibenzo[b,e]azepine, with the azepine ring fused to the e side of 4,5-dihydro-1H-imidazol-2-amine. It functions as an anti-allergic agent, histamine antagonist, ophthalmology drug, and H1-receptor antagonist. It belongs to the guanidines and benzazepine classes.

CAS No.80012-43-7
Product NameEpinastine

Biological Targets

HRH1

Associated Conditions

seasonal allergic rhinitis·allergic rhinitis·Rhinitis, Allergic, Perennial·eye allergy·allergic disease·
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Antihistamines in late-phase clinical development for allergic disease.

Expert opinion on investigational drugs • Vol. 11, Issue 2 • 2002
PMID: 11829715DOI: 10.1517/13543784.11.2.259

Histamine H1 receptors are involved in mouse nasal allergic responses: a demonstration with H1 receptor-deficient mice.

International immunopharmacology • Vol. 2, Issue 6 • 2002
PMID: 12095164DOI: 10.1016/s1567-5769(02)00010-3

Participation of chemical mediators other than histamine in nasal allergy signs: a study using mice lacking histamine H(1) receptors.

European journal of pharmacology • Vol. 449, Issue 3 • 2002
PMID: 12167471DOI: 10.1016/s0014-2999(02)02005-8

Dermal objective pharmacodynamic profile of cetirizine and epinastine: two controlled, randomised, double-blind, crossover studies.

International journal of clinical practice • Vol. 56, Issue 8 • 2002
PMID: 12425364

Documentation

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