Fludrocortisone acetate is an acetate ester formed by the condensation of the primary hydroxy group of fludrocortisone with acetic acid. It is a synthetic corticosteroid with glucocorticoid activity approximately 10 times that of hydrocortisone and mineralocorticoid activity over 100 times greater. Used in the treatment of primary and secondary adrenocortical insufficiency, including Addison's disease, and salt-losing adrenal hyperplasia. It is an 11beta-hydroxy, 3-oxo-Delta(4), 17alpha-hydroxy, 20-oxo steroid, a fluorinated steroid, an acetate ester, a mineralocorticoid, and a tertiary alpha-hydroxy ketone. Functionally related to fludrocortisone.
