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Chemical structure of CAS 495399-09-2

Saroglitazar

CAS No.495399-09-2
MDL No.MFCD28502034
MFC25H29NO4S
MW439.60
InChI KeyMRWFZSLZNUJVQW-DEOSSOPVSA-N
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Product Information

Saroglitazar is a monocarboxylic acid, specifically (2S)-2-ethoxy-3-(p-ethoxyphenyl)propanoic acid, in which one methyl hydrogen of the p-ethoxy substituent is replaced by the nitrogen of 2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrole. It is an agonist at PPAR alpha and gamma subtypes, with predominant PPARalpha activity, and is used in the treatment of type 2 diabetes. It functions as a PPARgamma agonist, hypoglycemic agent, and PPARalpha agonist. It belongs to the classes of pyrroles, monocarboxylic acids, methyl sulfides, and aromatic ethers.

CAS No.495399-09-2
Product NameSaroglitazar

Biological Targets

PPARA·PPARG

Associated Conditions

primary biliary cirrhosis·Hepatic steatosis·Disorder of lipid metabolism·cirrhosis of liver·liver disease·
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Effectiveness of Saroglitazar in MASLD Patients: A Prospective, Real-World Assessment of Liver and Metabolic Health.

Endocrinology, diabetes & metabolism • Vol. 9, Issue 1 • 2026
PMID: 41450117PMC: PMC12741649DOI: 10.1002/edm2.70144

Effect of Saroglitazar on Glycemic Status: A Meta-analysis.

Cureus • Vol. 17, Issue 12 • 2025
PMID: 41531617PMC: PMC12793644DOI: 10.7759/cureus.99122

Effect of Addition of Saroglitazar to Lifestyle Modifications in Patients with Nonalcoholic Fatty Liver Disease: A Prospective Observational Study.

Annals of African medicine • 2025
PMID: 41313090DOI: 10.4103/aam.aam_454_25

Impact of Saroglitazar on Liver Stiffness Measurements in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) With Compensated Cirrhosis: A Single-Arm Study.

Cureus • Vol. 17, Issue 9 • 2025
PMID: 41103905PMC: PMC12521542DOI: 10.7759/cureus.92313

Documentation

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