Sotalol

Sotalol is a sulfonamide with an N-phenylmethanesulfonamide structure, where the phenyl group at position 4 is substituted by a 1-hydroxy-2-(isopropylamino)ethyl group. It exhibits both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used, typically as the hydrochloride salt, for managing ventricular and supraventricular arrhythmias. It functions as a beta-adrenergic antagonist, anti-arrhythmia drug, environmental contaminant, and xenobiotic. It belongs to ethanolamines, secondary amino compounds, secondary alcohols, and sulfonamides. It is a conjugate base of sotalol(1+).