Product Information

CAS No.	328232-95-7
Product Name	MK-0557

Biological Targets

NPY5R

Associated Conditions

schizophrenia·obesity

* The information provided here is compiled from public sources and is for reference only.

Studies related to this compound and its mechanism of action

Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor.

Bioorganic & medicinal chemistry letters • Vol. 22, Issue 8 • 2012

PMID: 22445286 DOI: 10.1016/j.bmcl.2012.02.098

Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.

Bioorganic & medicinal chemistry • Vol. 17, Issue 19 • 2009

PMID: 19720539 DOI: 10.1016/j.bmc.2009.08.019

Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss.

Obesity (Silver Spring, Md.) • Vol. 15, Issue 4 • 2007

PMID: 17426325 DOI: 10.1038/oby.2007.620

NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine.

Obesity (Silver Spring, Md.) • Vol. 15, Issue 8 • 2007

PMID: 17712121 DOI: 10.1038/oby.2007.242

MK-0557

In Stock•Starting at $47 for 1 mg

CAS No.	328232-95-7
MDL No.	MFCD25976714
MF	C₂₂H₁₉FN₄O₃
MW	406.40
InChI Key	RMYZIRFUCOMQRH-UHFFFAOYSA-N

CUSTOM SYNTHESIS PRECLINICAL SUPPORT

Pricing & Availability

Pack Size	Purity	Price	Availability
1 mg	To Be Confirmed	$47	In Stock
5 mg	To Be Confirmed	$113	In Stock
10 mg	To Be Confirmed	$178	In Stock
25 mg	To Be Confirmed	$318	In Stock
50 mg	To Be Confirmed	$485	In Stock

Product Information

CAS No.	328232-95-7
Product Name	MK-0557

Biological Targets

NPY5R

Associated Conditions

schizophrenia·obesity

* The information provided here is compiled from public sources and is for reference only.

MK-0557

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

MK-0557

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

Documentation

MK-0557

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

Related Articles

Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor.

Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.

Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss.

NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine.

MK-0557

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

Related Articles

Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor.

Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.

Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss.

NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine.

Documentation