Product Information

CAS No.	284035-33-2
Product Name	NPS-2143

Heavy Atom Count	29	Rotatable Bond Count	8
Atom Stereo Count	1	Bond Stereo Count	0
HBA	4	HBD	2
TPSA	65.280 Å²	Charge	0
Exact Mass	408.16046	Complexity	1026.81
pKa	7.130	XLogP	4.715

Studies related to this compound and its mechanism of action

"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu Allosteric Ligands.

Molecular pharmacology • Vol. 93, Issue 5 • 2018

PMID: 29514854 DOI: 10.1124/mol.117.111518

Calcium-Sensing Receptor and Transient Receptor Ankyrin-1 Mediate Emesis Induction by Deoxynivalenol (Vomitoxin).

Toxicological sciences : an official journal of the Society of Toxicology • Vol. 155, Issue 1 • 2017

PMID: 27667315 PMC: PMC6366674 DOI: 10.1093/toxsci/kfw191

Potential roles for calcium-sensing receptor (CaSR) and transient receptor potential ankyrin-1 (TRPA1) in murine anorectic response to deoxynivalenol (vomitoxin).

Archives of toxicology • Vol. 91, Issue 1 • 2017

PMID: 26979077 DOI: 10.1007/s00204-016-1687-x

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.

Cell research • Vol. 26, Issue 5 • 2016

PMID: 27002221 PMC: PMC4856764 DOI: 10.1038/cr.2016.36

NPS-2143

CAS No.	284035-33-2
MDL No.	MFCD04113010
MF	C₂₄H₂₅ClN₂O₂
MW	408.90
InChI Key	PZUJQWHTIRWCID-HXUWFJFHSA-N

CUSTOM SYNTHESIS PRECLINICAL SUPPORT

Pricing & Availability

Pack Size	Purity	Price	Availability	Action
-	-	On Request	On Request
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.	284035-33-2
Product Name	NPS-2143

Heavy Atom Count	29	Rotatable Bond Count	8
Atom Stereo Count	1	Bond Stereo Count	0
HBA	4	HBD	2
TPSA	65.280 Å²	Charge	0
Exact Mass	408.16046	Complexity	1026.81
pKa	7.130	XLogP	4.715

NPS-2143

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Properties

NPS-2143

Pricing & Availability

Product Information

Properties

Documentation

NPS-2143

Pricing & Availability

Product Information

Properties

Related Articles

"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu Allosteric Ligands.

Calcium-Sensing Receptor and Transient Receptor Ankyrin-1 Mediate Emesis Induction by Deoxynivalenol (Vomitoxin).

Potential roles for calcium-sensing receptor (CaSR) and transient receptor potential ankyrin-1 (TRPA1) in murine anorectic response to deoxynivalenol (vomitoxin).

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.

NPS-2143

Pricing & Availability

Product Information

Properties

Related Articles

"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu Allosteric Ligands.

Calcium-Sensing Receptor and Transient Receptor Ankyrin-1 Mediate Emesis Induction by Deoxynivalenol (Vomitoxin).

Potential roles for calcium-sensing receptor (CaSR) and transient receptor potential ankyrin-1 (TRPA1) in murine anorectic response to deoxynivalenol (vomitoxin).

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.

Documentation