Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction.
Journal of medicinal chemistry • Vol. 65, Issue 14 • 2022
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.
Cancer discovery • Vol. 11, Issue 1 • 2021
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Proceedings of the National Academy of Sciences of the United States of America • Vol. 116, Issue 7 • 2019
The role of saliva in the control of pH changes in human dental plaque.
Caries research • Vol. 10, Issue 4 • 1976
