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Chemical structure of CAS 2417987-45-0

Divarasib

In Stock•Starting at $149 for 5 mg•Purity ≥ 98%
CAS No.2417987-45-0
MDL No.N/A
MFC29H32ClF4N7O2
MW622.10
InChI KeyZRBPIAWWRPFDPY-IRXDYDNUSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT→

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
5 mg≥98%$149In Stock
10 mg≥98%$253In Stock
25 mg≥98%$493In Stock
100 mg≥98%$1419In Stock
1 g98%$4745In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.2417987-45-0
Product NameDivarasib

Associated Conditions

neoplasm·non-small cell lung carcinoma
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C.

Journal of medicinal chemistry • Vol. 69, Issue 5 • 2026
PMID: 41766690PMC: PMC12990036DOI: 10.1021/acs.jmedchem.5c02272

Binding modes of the KRAS(G12C) inhibitors GDC-6036 and LY3537982 revealed by all atom molecular dynamics simulations.

Scientific reports • Vol. 15, Issue 1 • 2025
PMID: 40640254PMC: PMC12246139DOI: 10.1038/s41598-025-07532-2

Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.

Journal of the American Chemical Society • Vol. 144, Issue 45 • 2022
PMID: 36326518DOI: 10.1021/jacs.2c09917

Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach.

Analytical chemistry • Vol. 94, Issue 37 • 2022
PMID: 36083155DOI: 10.1021/acs.analchem.2c03146

Documentation

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