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Chemical structure of CAS 218600-53-4

Bardoxolone Methyl

CAS No.218600-53-4
MDL No.MFCD11983137
MFC32H43NO4
MW505.70
InChI KeyWPTTVJLTNAWYAO-KPOXMGGZSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
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Product Information

Bardoxolone methyl is a cyclohexenone.

CAS No.218600-53-4
Product NameBardoxolone Methyl

Biological Targets

PPARG·IKBKB·NFE2L2·KEAP1

Associated Conditions

pulmonary arterial hypertension·melanoma·neoplasm·COVID-19·diabetic nephropathy·
* The information provided here is compiled from public sources and is for reference only.

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Studies related to this compound and its mechanism of action

Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids.

Toxicological sciences : an official journal of the Society of Toxicology • Vol. 140, Issue 2 • 2014
PMID: 24798383PMC: PMC4120102DOI: 10.1093/toxsci/kfu080

Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway.

Toxicology • Vol. 318 • 2014
PMID: 24530882DOI: 10.1016/j.tox.2014.01.008

Immunosuppressive potential of bardoxolone methyl using a modified murine local lymph node assay (LLNA).

The Journal of toxicological sciences • Vol. 39, Issue 4 • 2014
PMID: 25056779DOI: 10.2131/jts.39.545

Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.

Neoplasia (New York, N.Y.) • Vol. 16, Issue 9 • 2014
PMID: 25246272PMC: PMC4234881DOI: 10.1016/j.neo.2014.07.012

Documentation

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