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Chemical structure of CAS 2180923-05-9

Lisaftoclax

In Stock•Starting at $121 for 1 mg•Purity ≥ 98%
CAS No.2180923-05-9
MDL No.N/A
MFC45H48ClN7O8S
MW882.40
InChI KeyFNBXDBIYRAPDPI-BHVANESWSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mg98%$121In Stock
5 mg98%$282In Stock
25 mg98%$739In Stock
100 mg98%$1595In Stock
250 mg98%$3187In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.2180923-05-9
Product NameLisaftoclax
Heavy Atom Count62Rotatable Bond Count13
Atom Stereo Count1Bond Stereo Count0
HBA12HBD3
TPSA181.260 ŲCharge0
Exact Mass881.29736Complexity2618.12
pKa11.873XLogP7.793

Related Articles

Studies related to this compound and its mechanism of action

FLT3 inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor lisaftoclax (APG-2575) in preclinical models of FLT3-ITD mutant acute myeloid leukemia.

Translational oncology • Vol. 15, Issue 1 • 2022
PMID: 34710737PMC: PMC8556530DOI: 10.1016/j.tranon.2021.101244

A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma.

Oncology research • Vol. 28, Issue 4 • 2020
PMID: 32093809PMC: PMC7851508DOI: 10.3727/096504020X15825405463920

Interaction of tropomyosin with troponin components.

Journal of biochemistry • Vol. 80, Issue 1 • 1976
PMID: 9383DOI: 10.1093/oxfordjournals.jbchem.a131262

Documentation

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