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Chemical structure of CAS 2114324-48-8

Tak-925

In Stock•Starting at $908 for 1 mg•Purity ≥ 98.36%
CAS No.2114324-48-8
MDL No.N/A
MFC21H32N2O5S
MW424.60
InChI KeyUXZAJSZFFARTEI-GUMHCPJTSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT→

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mg98.36%$908In Stock
5 mg98.36%$2256In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.2114324-48-8
Product NameTak-925

Associated Conditions

narcolepsy·sleep apnea·idiopathic hypersomnia·obstructive sleep apnea·narcolepsy-cataplexy syndrome
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice.

Journal of sleep research • Vol. 32, Issue 4 • 2023
PMID: 36808670PMC: PMC10356740DOI: 10.1111/jsr.13839

Danavorexton, a selective orexin 2 receptor agonist, provides a symptomatic improvement in a narcolepsy mouse model.

Pharmacology, biochemistry, and behavior • Vol. 220 • 2022
PMID: 36108771DOI: 10.1016/j.pbb.2022.173464

Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients.

Proceedings of the National Academy of Sciences of the United States of America • Vol. 119, Issue 35 • 2022
PMID: 35994639PMC: PMC9436334DOI: 10.1073/pnas.2207531119

TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice.

Pharmacology, biochemistry, and behavior • Vol. 187 • 2019
PMID: 31654653DOI: 10.1016/j.pbb.2019.172794

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