DempoChem Logo
  1. HomeHome
  2. /ProductsProducts
  3. /Building BlocksBuilding Blocks
  4. /Heterocyclic ScaffoldsHeterocyclic Scaffolds
  5. /IndazolesIndazoles
  6. /CulmerciclibCulmerciclib
Chemical structure of CAS 2004705-28-4

Culmerciclib

CAS No.2004705-28-4
MDL No.N/A
MFC24H27FN8
MW446.50
InChI KeyLLFOBMRPWNABCB-UHFFFAOYSA-N
CUSTOM SYNTHESIS

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
- -On RequestOn Request
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.2004705-28-4
Product NameCulmerciclib
Heavy Atom Count33Rotatable Bond Count5
Atom Stereo Count0Bond Stereo Count0
HBA8HBD2
TPSA83.790 ŲCharge0
Exact Mass446.23427Complexity1275.86
pKa9.247XLogP3.841

Related Articles

Studies related to this compound and its mechanism of action

Approvals by the China NMPA in 2025.

Nature reviews. Drug discovery • Vol. 25, Issue 3 • 2026
PMID: 41688808DOI: 10.1038/d41573-026-00028-2

Novel CDK2/4/6 inhibitor culmerciclib (TQB3616) plus fulvestrant in previously treated, HR-positive, HER2-negative advanced breast cancer: a randomized, double-blind, phase 3 trial.

Signal transduction and targeted therapy • Vol. 10, Issue 1 • 2025
PMID: 41413016PMC: PMC12714862DOI: 10.1038/s41392-025-02475-6

Discovery and preclinical evaluations of TQB3616, a novel CDK4-biased inhibitor.

Bioorganic & medicinal chemistry letters • Vol. 107 • 2024
PMID: 38670537DOI: 10.1016/j.bmcl.2024.129769

The Potent Novel CDK4/6 Inhibitor TQB3616 in Hormone Receptor Positive Breast Cancer: Preclinical Characterization with in vitro and Human Tumor Xenograft Models.

Breast cancer (Dove Medical Press) • Vol. 15 • 2023
PMID: 38090281PMC: PMC10715022DOI: 10.2147/BCTT.S434973

Documentation

Similar Products

  • Eciruciclib

    CAS No.1868086-40-1

Your Partner for
Complex Chemistry
logo
  • About Us
  • Perspectives
  • Products
  • Contact
  • Preclinical Development
  • Technologies
  • Custom Synthesis
Ready to start your project?

Provide your target molecule or project specifications to align on a tailored development and scale-up pathway with our scientific team.

START A PROJECT
Westerstraat 10, 3016 DH, Rotterdam, The Netherlands
Westerstraat 10, 3016 DH, Rotterdam, The Netherlands
logo

All products are supplied strictly for research and development use only and are not intended for human or veterinary administration, diagnostic use, or therapeutic use. Preclinical and related services are provided solely for research and development purposes and do not constitute clinical diagnosis, treatment, or veterinary care.

©2026 DempoChem. All Rights Reserved.
DHLFedExUPSPostNL
CLIENT PORTAL|TERMS AND CONDITIONS|PRIVACY POLICY|
  • Products
    • CDMO Compounds
    • API & Candidates
  • Services
    CDMO & Manufacturing
    • Custom Synthesis
    • Process Development
    • Lab To Pilot
    • Commercialization
    • Generic APIs
    CRO
    • Preclinical
    • Pharmacology & Efficacy
    • DMPK & Bioanalysis
    • Toxicology & Safety
    • Disease Models
    Technologies
    • High-Potent
    • Chiral Synthesis
    • Cloud Synthesis
    • Fermentation
    • Flow Chemistry
    • Biocatalysis
    Support
    • Regulatory Support
    • Supply Chain Solutions
  • About
  • Perspectives
  • Contact