Lomitapide is a benzamide formed by the formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. It is used as its mesylate salt in conjunction with a low-fat diet and other lipid-lowering therapies for patients with homozygous familial hypercholesterolemia. It functions as an anticholesteremic drug and MTP inhibitor. It belongs to piperidines, fluorenes, benzamides, and (trifluoromethyl)benzenes. It is the conjugate base of lomitapide(1+).
