Teriflunomide

Teriflunomide is an enamide formed by the condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. It is used to treat relapsing forms of multiple sclerosis and rheumatoid arthritis. Teriflunomide acts as an inhibitor of EC 1.3.98.1 [dihydroorotate oxidase (fumarate)], a tyrosine kinase, and a hepatotoxic agent. It is also a drug metabolite, a non-steroidal anti-inflammatory drug, a nitrile, an enol, an aromatic amide, an enamide, a member of (trifluoromethyl)benzenes, and a secondary carboxamide.