Zuranolone is a 3-hydroxy steroid, specifically a 5β-19-norpregnane derivative substituted with hydroxy, methyl, oxo, and 4-cyano-1H-pyrazol-1-yl groups at positions 3, 3, 20, and 21, respectively. It is a positive allosteric modulator of the GABAA receptor developed by Sage Therapeutics and Biogen for the treatment of postpartum depression in adults. It functions as an antidepressant, GABA modulator, and anticonvulsant. It is classified as a nitrile, a pyrazole, a 3-hydroxy steroid, and a 20-oxo steroid.
