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  6. /2-((S)-1-((2S,5R)-5-(4-chloro-5-fluoro-2-(trifluoromethyl)phenyl)tetrahydrofuran-2-yl)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dioneCAS 1587727-31-8
Chemical structure of CAS 1587727-31-8

2-((S)-1-((2S,5R)-5-(4-chloro-5-fluoro-2-(trifluoromethyl)phenyl)tetrahydrofuran-2-yl)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

In Stock•Starting at $1641 for 1 mg•Purity ≥ 98.12%
CAS No.1587727-31-8
MDL No.N/A
MFC25H23ClF4N4O3
MW538.90
InChI KeyAKCDDYGYIGPEKL-JQOQJDEVSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT→

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mg98.12%$1641In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.1587727-31-8
Product Name2-((S)-1-((2S,5R)-5-(4-chloro-5-fluoro-2-(trifluoromethyl)phenyl)tetrahydrofuran-2-yl)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione
Heavy Atom Count37Rotatable Bond Count4
Atom Stereo Count3Bond Stereo Count0
HBA6HBD0
TPSA69.360 ŲCharge0
Exact Mass538.13948Complexity1434.27
pKa9.613XLogP4.918

Related Articles

Studies related to this compound and its mechanism of action

Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.

Journal of medicinal chemistry • Vol. 67, Issue 12 • 2024
PMID: 38848667DOI: 10.1021/acs.jmedchem.4c00580

Lessons from a failed γ-secretase Alzheimer trial.

Cell • Vol. 159, Issue 4 • 2014
PMID: 25417150DOI: 10.1016/j.cell.2014.10.016

Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease.

Archives of neurology • Vol. 69, Issue 11 • 2012
PMID: 22892585DOI: 10.1001/archneurol.2012.2194

Documentation

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