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Chemical structure of CAS 147536-97-8

Bosentan

In Stock•Starting at $64 for 50 mg•Purity ≥ 98%
CAS No.147536-97-8
MDL No.N/A
MFC27H29N5O6S
MW551.60
InChI KeyGJPICJJJRGTNOD-UHFFFAOYSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
50 mg98%$64In Stock
100 mg98%$109In Stock
250 mg98%$253In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

Bosentan is a sulfonamide, a pyrimidine derivative, and a primary alcohol. It functions as an antihypertensive agent and an endothelin receptor antagonist.

CAS No.147536-97-8
Product NameBosentan

Biological Targets

EDNRB·EDNRA

Associated Conditions

idiopathic pulmonary fibrosis·persistent fetal circulation syndrome·congestive heart failure·hypertension·sleep apnea·
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Endothelin receptor blockade improves endothelial function in human internal mammary arteries.

Cardiovascular research • Vol. 49, Issue 1 • 2001
PMID: 11121806DOI: 10.1016/s0008-6363(00)00244-3

Endothelin receptor antagonist prevents parathyroid cell proliferation of low calcium diet-induced hyperparathyroidism in rats.

Endocrinology • Vol. 142, Issue 1 • 2001
PMID: 11145604DOI: 10.1210/endo.142.1.7884

Combined blockade of endothelin-1 and thromboxane A(2) receptors against postischaemic contractile dysfunction in rat hearts.

British journal of pharmacology • Vol. 132, Issue 1 • 2001
PMID: 11156582PMC: PMC1572531DOI: 10.1038/sj.bjp.0703773

Pressure overload increases GATA4 binding activity via endothelin-1.

Circulation • Vol. 103, Issue 5 • 2001
PMID: 11156886DOI: 10.1161/01.cir.103.5.730

Documentation

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