Product Information

CAS No.	1435467-37-0
Product Name	Pf-06282999

Heavy Atom Count	21	Rotatable Bond Count	4
Atom Stereo Count	0	Bond Stereo Count	0
HBA	5	HBD	2
TPSA	90.110 Å²	Charge	0
Exact Mass	325.02879	Complexity	813.04
pKa	7.130	XLogP	1.720

Studies related to this compound and its mechanism of action

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology.

Immunology • Vol. 160, Issue 1 • 2020

PMID: 32020584 PMC: PMC7160657 DOI: 10.1111/imm.13175

Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans.

Drug metabolism and disposition: the biological fate of chemicals • Vol. 44, Issue 2 • 2016

PMID: 26608081 DOI: 10.1124/dmd.115.067868

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.

Journal of medicinal chemistry • Vol. 58, Issue 21 • 2015

PMID: 26509551 DOI: 10.1021/acs.jmedchem.5b00963

Mismatch correction in pneumococcal transformation: donor length and hex-dependent marker efficiency.

Journal of bacteriology • Vol. 125, Issue 1 • 1976

PMID: 1370 PMC: PMC233343 DOI: 10.1128/jb.125.1.125-135.1976

Pf-06282999

CAS No.	1435467-37-0
MDL No.	N/A
MF	C₁₃H₁₂ClN₃O₃S
MW	325.77
InChI Key	ICYNYWFGIDGBRD-UHFFFAOYSA-N

CUSTOM SYNTHESIS PRECLINICAL SUPPORT

Pricing & Availability

Pack Size	Purity	Price	Availability	Action
-	-	On Request	On Request
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.	1435467-37-0
Product Name	Pf-06282999

Heavy Atom Count	21	Rotatable Bond Count	4
Atom Stereo Count	0	Bond Stereo Count	0
HBA	5	HBD	2
TPSA	90.110 Å²	Charge	0
Exact Mass	325.02879	Complexity	813.04
pKa	7.130	XLogP	1.720

Pf-06282999

Pricing & Availability

Product Information

Properties

Pf-06282999

Pricing & Availability

Product Information

Properties

Documentation

Pf-06282999

Pricing & Availability

Product Information

Properties

Related Articles

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology.

Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans.

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.

Mismatch correction in pneumococcal transformation: donor length and hex-dependent marker efficiency.

Pf-06282999

Pricing & Availability

Product Information

Properties

Related Articles

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology.

Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans.

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.

Mismatch correction in pneumococcal transformation: donor length and hex-dependent marker efficiency.

Documentation