Characterization of recent non-fentanyl synthetic opioids via three different in vitro µ-opioid receptor activation assays.
Archives of toxicology • Vol. 96, Issue 3 • 2022
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.
Journal of medicinal chemistry • Vol. 59, Issue 18 • 2016
A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain.
Pain • Vol. 157, Issue 1 • 2016
Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers.
Pain • Vol. 155, Issue 9 • 2014