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Chemical structure of CAS 136087-85-9

Fidarestat

In Stock•Starting at $138 for 1 mg
CAS No.136087-85-9
MDL No.N/A
MFC12H10FN3O4
MW279.22
InChI KeyWAAPEIZFCHNLKK-UFBFGSQYSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mgTo Be Confirmed$138In Stock
5 mgTo Be Confirmed$391In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.136087-85-9
Product NameFidarestat
Heavy Atom Count20Rotatable Bond Count1
Atom Stereo Count2Bond Stereo Count0
HBA4HBD3
TPSA110.520 ŲCharge0
Exact Mass279.06553Complexity647.59
pKa7.130XLogP-0.503

Related Articles

Studies related to this compound and its mechanism of action

X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.

Chemico-biological interactions • Vol. 202, Issue 1-3 • 2013
PMID: 23295227DOI: 10.1016/j.cbi.2012.12.013

Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat.

PloS one • Vol. 7, Issue 1 • 2012
PMID: 22253906PMC: PMC3257265DOI: 10.1371/journal.pone.0030134

Aldose reductase inhibition prevents metaplasia of airway epithelial cells.

PloS one • Vol. 5, Issue 12 • 2010
PMID: 21203431PMC: PMC3010981DOI: 10.1371/journal.pone.0014440

Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress.

Chemico-biological interactions • Vol. 178, Issue 1-3 • 2009
PMID: 18845131DOI: 10.1016/j.cbi.2008.09.010

Documentation

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