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Chemical structure of CAS 130-15-4

1,4-Naphthoquinone

CAS No.130-15-4
MDL No.MFCD00001676
MFC10H6O2
MW158.15
InChI KeyFRASJONUBLZVQX-UHFFFAOYSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT

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Product Information

1,4-Naphthoquinone is the parent structure of the 1,4-naphthoquinone family, with oxo groups at positions 1 and 4 of the naphthalene ring. Derivatives exhibit pharmacological properties and are derived from a naphthalene hydride.

CAS No.130-15-4
Product Name1,4-Naphthoquinone
CorrosiveCorrosive
Acute ToxicAcute Toxic
IrritantIrritant
Health HazardHealth Hazard
Environmental HazardEnvironmental Hazard
Signal Word:Danger
HCode:H301-H314-H315-H317-H318-H319-H330-H334-H335-H400-H410-H371-H373
PCode:P233-P260-P261-P264-P264+P265-P270-P271-P272-P273-P280-P284-P301+P316-P301+P330+P331-P302+P352-P302+P361+P354-P304+P340-P305+P351+P338-P305+P354+P338-P316-P317-P319-P320-P321-P330-P332+P317-P333+P317-P337+P317-P342+P316-P362+P364-P363-P391-P403-P403+P233-P405-P501-P308+P316

Related Articles

Studies related to this compound and its mechanism of action

Caspase-3-mediated cleavage of the NF-kappa B subunit p65 at the NH2 terminus potentiates naphthoquinone analog-induced apoptosis.

The Journal of biological chemistry • Vol. 276, Issue 27 • 2001
PMID: 11320092DOI: 10.1074/jbc.M101291200

2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

Journal of medicinal chemistry • Vol. 44, Issue 4 • 2001
PMID: 11170645DOI: 10.1021/jm001079l

In vitro and in vivo Leishmanicidal activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol).

Phytotherapy research : PTR • Vol. 15, Issue 1 • 2001
PMID: 11180522DOI: 10.1002/1099-1573(200102)15:1<44::aid-ptr685>3.0.co;2-1

NAD(P)H:menadione oxidoreductase of the amitochondriate eukaryote Giardia lamblia: a simpler homologue of the vertebrate enzyme.

Microbiology (Reading, England) • Vol. 147, Issue Pt 3 • 2001
PMID: 11238963DOI: 10.1099/00221287-147-3-561

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