Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.
Journal of medicinal chemistry • Vol. 64, Issue 19 • 2021
Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease.
The New England journal of medicine • Vol. 380, Issue 15 • 2019
Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer's Disease.
The New England journal of medicine • Vol. 378, Issue 18 • 2018
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
Journal of medicinal chemistry • Vol. 59, Issue 23 • 2016
