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Chemical structure of CAS 1210608-43-7

Lgh-447

In Stock•Starting at $101 for 1 mg•Purity ≥ 98%
CAS No.1210608-43-7
MDL No.N/A
MFC24H23F3N4O
MW440.50
InChI KeyVRQXRVAKPDCRCI-ZNMIVQPWSA-N
CUSTOM SYNTHESIS

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mg98%$101In Stock
5 mg98%$251In Stock
10 mg98%$399In Stock
25 mg98%$755In Stock
50 mg98%$1221In Stock
100 mg98%$2166In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.1210608-43-7
Product NameLgh-447
Heavy Atom Count32Rotatable Bond Count4
Atom Stereo Count3Bond Stereo Count0
HBA4HBD2
TPSA80.900 ŲCharge0
Exact Mass440.18240Complexity1123.59
pKa7.130XLogP5.044

Related Articles

Studies related to this compound and its mechanism of action

The first-in-human study of the pan-PIM kinase inhibitor PIM447 in patients with relapsed and/or refractory multiple myeloma.

Leukemia • Vol. 33, Issue 12 • 2019
PMID: 31092894DOI: 10.1038/s41375-019-0482-0

Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

Journal of medicinal chemistry • Vol. 58, Issue 21 • 2015
PMID: 26505898DOI: 10.1021/acs.jmedchem.5b01275

Documentation