1,1'-(9-(2-((1-Methylethyl)amino)ethyl)-9H-carbazole-3,6-diyl)bis(ethanone)
In Stock•Starting at $104 for 10 mg•Purity ≥ 98%
| CAS No. | 1197996-80-7 |
|---|---|
| MDL No. | N/A |
| MF | C21H24N2O2 |
| MW | 336.40 |
| InChI Key | JKCSODVERGVDLT-UHFFFAOYSA-N |
Pricing & Availability
| Pack Size | Purity | Price | Availability | Action |
|---|---|---|---|---|
| 10 mg | 98% | $104 | In Stock | |
| 25 mg | 98% | $119 | In Stock | |
| 50 mg | 98% | $201 | In Stock | |
| 100 mg | 98% | $338 | In Stock | |
| 250 mg |
Product Information
CBL0137 is a 9H-carbazole substituted with acetyl groups at positions 3 and 6, and a 2-isopropylethyl group at the nitrogen atom (position 9). It modulates the histone chaperone FACT, leading to NF-κB suppression, HSF1 suppression, and p53 activation, and exhibits antitumour effects in various cancer animal models. CBL0137 functions as a NF-κB inhibitor, p53 activator, antineoplastic agent, and apoptosis inducer. It belongs to the class of carbazoles, secondary and tertiary amino compounds, and aromatic and methyl ketones.
| CAS No. | 1197996-80-7 |
|---|---|
| Product Name | 1,1'-(9-(2-((1-Methylethyl)amino)ethyl)-9H-carbazole-3,6-diyl)bis(ethanone) |
| Heavy Atom Count | 25 | Rotatable Bond Count | 6 |
| Atom Stereo Count | 0 | Bond Stereo Count | 0 |
| HBA | 4 | HBD | 1 |
| TPSA | 51.100 Ų | Charge | 0 |
| Exact Mass | 336.18378 | Complexity | 895.59 |
| pKa | 5.875 | XLogP | 4.198 |