1,1'-(9-(2-((1-Methylethyl)amino)ethyl)-9H-carbazole-3,6-diyl)bis(ethanone)

CBL0137 is a 9H-carbazole substituted with acetyl groups at positions 3 and 6, and a 2-isopropylethyl group at the nitrogen atom (position 9). It modulates the histone chaperone FACT, leading to NF-κB suppression, HSF1 suppression, and p53 activation, and exhibits antitumour effects in various cancer animal models. CBL0137 functions as a NF-κB inhibitor, p53 activator, antineoplastic agent, and apoptosis inducer. It belongs to the class of carbazoles, secondary and tertiary amino compounds, and aromatic and methyl ketones.