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Chemical structure of CAS 117704-25-3

Doramectin

In Stock•Starting at $14 for 100 mg•Purity ≥ 97%
CAS No.117704-25-3
MDL No.MFCD00894747
MFC50H74O14
MW899.10
InChI KeyQLFZZSKTJWDQOS-YDBLARSUSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
100 mg98%$14In Stock
250 mg98%$19In Stock
1 g97%$34In Stock
5 g97%$93In Stock
10 g97%$166In Stock
25 g97%$370In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.117704-25-3
Product NameDoramectin
Acute ToxicAcute Toxic
IrritantIrritant
Health HazardHealth Hazard
Environmental HazardEnvironmental Hazard
Signal Word:Danger
HCode:H300-H301-H302-H360-H361-H362-H370-H372-H400-H410
PCode:P203-P260-P263-P264-P270-P273-P280-P301+P316-P301+P317-P308+P316-P318-P319-P321-P330-P391-P405-P501

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Studies related to this compound and its mechanism of action

P-gp substrate-induced neurotoxicity in an Abcb1a knock-in/Abcb1b knock-out mouse model with a mutated canine ABCB1 targeted insertion.

Research in veterinary science • Vol. 94, Issue 3 • 2013
PMID: 23186803DOI: 10.1016/j.rvsc.2012.10.025

Moxidectin has a lower neurotoxic potential but comparable brain penetration in P-glycoprotein-deficient CF-1 mice compared to ivermectin.

Journal of veterinary pharmacology and therapeutics • Vol. 36, Issue 3 • 2013
PMID: 22834856DOI: 10.1111/j.1365-2885.2012.01424.x

Effects of avermectins on neurite outgrowth in differentiating mouse neuroblastoma N2a cells.

Toxicology letters • Vol. 192, Issue 2 • 2010
PMID: 19879343DOI: 10.1016/j.toxlet.2009.10.021

Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin.

The Journal of pharmacy and pharmacology • Vol. 62, Issue 3 • 2010
PMID: 20487225DOI: 10.1211/jpp.62.03.0016

Documentation

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