SB-743921 is a chromone (4H-chromen-4-one) substituted at positions 2, 3, and 7 with (1R)-1-[(3-aminopropyl)(4-methylbenzoyl)amino]-2-methylpropyl, benzyl, and chloro groups, respectively. It is a potent kinesin spindle protein inhibitor (Ki = 0.1 nM) with antineoplastic activity. It acts as an apoptosis inducer, antineoplastic agent, and microtubule-destabilizing agent. It belongs to benzenes, toluenes, benzamides, tertiary carboxamides, primary amino compounds, chromones, and organochlorine compounds.
