Vactosertib
CandidateCAS: 1352608-82-2
Sample Stock:
Vactosertib exerts its effects by inhibiting a key cellular signaling pathway called TGF-β, thereby achieving dual anti-tumor and anti-fibrotic effects. It is currently undergoing multiple clinical trials to evaluate its efficacy in treating various solid tumors such as esophageal adenocarcinoma, and osteosarcoma,either alone or in combination with chemotherapy and immunotherapy (such as pembrolizumab).
Related Information
Purity:98%+
Registration:GMP/DMF
Biological Profile
Biological Targets
TGFBR1
Associated Conditions
osteosarcoma·pancreatic carcinoma·non-small cell lung carcinoma·Desmoid-type fibromatosis·myeloproliferative disorder·
Key Intermediates
7 Items| Structure | Name | CAS No. | Sample Stock | MDL No. | Details |
|---|---|---|---|---|---|
![1-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione structure](https://static.dempochem.com/structures-bw/6952b14d061d1447e2c2b436.svg) | 1-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione | 356560-84-4 | MFCD11111125 | ||
![6-((6-Methylpyridin-2-yl)ethynyl)-[1,2,4]triazolo[1,5-a]pyridine structure](https://static.dempochem.com/structures-bw/6952b120061d1447e2c2b435.svg) | 6-((6-Methylpyridin-2-yl)ethynyl)-[1,2,4]triazolo[1,5-a]pyridine | 356560-83-3 | - | ||
![6-Ethynyl-[1,2,4]triazolo[1,5-a]pyridine structure](https://static.dempochem.com/structures-bw/6952b0ff061d1447e2c2b434.svg) | 6-Ethynyl-[1,2,4]triazolo[1,5-a]pyridine | 356560-82-2 | - | ||
![6-((Trimethylsilyl)ethynyl)-[1,2,4]triazolo[1,5-a]pyridine structure](https://static.dempochem.com/structures-bw/6952b0d5061d1447e2c2b433.svg) | 6-((Trimethylsilyl)ethynyl)-[1,2,4]triazolo[1,5-a]pyridine | 356560-81-1 | - | ||
 | 6-Bromo-(1,2,4)triazolo(1,5-a)pyridine | 356560-80-0 | MFCD08689534 | ||
![4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazole-2-carbaldehyde structure](https://static.dempochem.com/structures-bw/6952b07c061d1447e2c2b431.svg) | 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazole-2-carbaldehyde | 1352609-91-6 | MFCD28506210 | ||
![6-(2-(Dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine structure](https://static.dempochem.com/structures-bw/6952b02d061d1447e2c2b430.svg) | 6-(2-(Dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine | 1352609-89-2 | - |