Itacitinib

Candidate

Sample Stock:

Itacitinib is an investigational oral drug that selectively inhibits the Janus kinase 1 (JAK1) enzyme. It is being evaluated in clinical trials for its potential to treat various solid tumors and hematologic malignancies by targeting pathways that drive tumor growth and inflammation.

Related Information

Purity:98%+

Registration:GMP/DMF

Biological Profile

Biological Targets

JAK1

Associated Conditions

classic Hodgkin lymphoma·graft versus host disease·hematopoietic and lymphoid cell neoplasm·hemophagocytic syndrome·lung cancer·

Key Intermediates

15 Items

Name	CAS No.	MDL No.
3-Cyanomethyleneazetidinium chloride	1314910-43-4	MFCD19227479
1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole	1029716-44-6	MFCD11857753
1-Boc-3-azetidinone	398489-26-4	MFCD01861741
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine	1153949-11-1	MFCD12761241
4-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)-1H-pyrazole	1239322-61-2	-
tert-butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate	1153949-15-5	MFCD28401390
tert-Butyl 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)azetidine-1-carboxylate	1627504-41-9	-
2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitriledihydrochloride	1627504-43-1	-
1-(3-Fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-one	1334303-99-9	MFCD29086409
2-(1-(1-(3-Fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-ylidene)acetonitrile	1627504-45-3	-
1-(ethoxyethyl)-4-bromo-1H-pyrazole	1024120-52-2	MFCD22543653
(E)-6-Chloro-5-(2-methoxyvinyl)pyrimidin-4-amine	2092876-49-6	MFCD11857753
Tert-butyl 3-hydroxyazetidine-1-carboxylate	141699-55-0	MFCD04115305
3-Fluoro-2-(trifluoromethyl)isonicotinic acid	886510-09-4	MFCD08437597
4-Iodo-1-(trimethylsilyl)-1H-pyrazole	189332-05-6	-